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KMID : 0380620190510040393
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Korean Journal of Food Science and Technology
2019 Volume.51 No. 4 p.393 ~ p.397
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Effects of persimmon leaf extracts on proteasome activity in HepG2 human liver cancer cells
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Kim So-Young
Yoon Hyun-Geun
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Abstract
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Proteasome inhibitors can promote apoptosis and cell cycle arrest in cancer cells by inhibition of nuclear factorkappaB (NF-κB) activation. The purpose of this study was to investigate the effects of persimmon leaf extract (PSE) on proteasome activity in HepG2 human liver cancer cells. PSE treatment inhibited the proteasome activity and NF-κB activation in a dose-dependent manner in HepG2 human liver cancer cells (p<0.05). PSE treatment increased the population of cells in G2/M and sub-G1 phases. The results suggested that PSE is one of the candidate substances that may be developed into a proteasome inhibitor.
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KEYWORD
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proteasome inhibitor, NF-κB, persimmon leaf extracts, HepG2 cells
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